Dimethylamine → HCID 11673337, compound

Participants

Reaction Steps

A solution of 6-hydroxy-5,7,8-trimethylspiro[chromene-2,1′-cyclobutan]-4(3H)-one (220 mg), formaldehyde (1 mL, 37% in water), dimethylamine solution (1 mL, 2.0 M in methanol), and concentrated HCl water solution (0.1, mL) was heated by microwave to 150° C. for 10 min. The allyl intermediate was treated with excessive NaBH4 in methanol at room temperature to give 6-hydroxy-3,5,7,8-tetramethylspiro[chromene-2,1′-cyclobutan]-4(3H)-one, which was purified by chromatography (silica gel, hexane-ethyl acetate 3%).

Provenance & Evidence