Potassium Carbonate → HCID 11514714, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-hydroxy-5,7-dimethylspiro[chromene-2,1′-cyclobutane]-3-carbaldehyde (315 mg), prepared as described herein, in 4 mL of MeOH was added tosylmethyl isocyanide (TosMIC) reagent (218 mg) and potassium carbonate (310 mg). The reaction mixture was allowed to heat at 80° C. for 20 min. The mixture was quenched with water and extracted with ethyl acetate. After concentrated in vacuo, the residue was purified by flash chromatography eluted with 30% ethyl acetate in hexane to give 118.8 mg of 5,7-dimethyl-3-(1,3-oxazol-5-yl)spiro[chromene-2,1′-cyclobutan]-6-ol as a yellow solid.

Provenance & Evidence