Aluminium lithium hydride → HCID 57803535, compound

Participants

Reaction Steps

To a solution of 5-ethyl-7-isopropyl-4-oxospiro[chroman-2,1′-cyclobutane]-6-yl acetate (53 mg) in 5 mL of THF was added LiAlH4 (65 mg) in 3 portions at room temperature. The mixture was stirred for 2 h and quenched by pouring onto ice. The mixture was extracted with EtOAc (3×10 mL) and the organic extract was dried over Na2SO4 and concentrated. The crude product was purified by chromatography to afford 5-ethyl-7-isopropylspiro[chroman-2,1′-cyclobutane]-4,6-diol as an off-white solid (29 mg, 63%).

Provenance & Evidence