Boron tribromide → HCID 86605500, compound

Participants

Reaction Steps

1-(6′-methoxy-7′,8′-dimethyl-2′,4′-dihydro-1′H-spiro[cyclobutane-1,3′-quinoline]-1′-yl)ethanone (100 mg) was dissolved in dichloromethane (2 mL), to which solution was added BBr3 (19.3 mL) at 10° C. After 1.5 h, it was quenched with water, extracted with dichloromethane, and the organic layers were washed with brine, dried and evaporated to give an oil. Elution on a column (dichloromethane:methanol=10:0.2) gave 6′-hydroxy-7′,8′-dimethyl-2′,4′-dihydro-1′H-spiro[cyclobutane-1,3′-quinoline]-1′-carbaldehyde (70 mg) as a white solid.

Provenance & Evidence