Sodium Hydroxide → HCID 22475247, compound

HRID 2103146Notes

Reaction equation

HRID 2103146 reaction equation
C([O:3][C:4]([C:6]1[CH:30]=[CH:29][C:9]2[O:10][C:11]([C:21]3[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[CH:22]=3)([C:13]3[CH:18]=[C:17]([F:19])[CH:16]=[C:15]([F:20])[CH:14]=3)[O:12][C:8]=2[CH:7]=1)=[O:5])C.[OH-].[Na+]>C(O)C>[F:28][C:23]1[CH:22]=[C:21]([C:11]2([C:13]3[CH:18]=[C:17]([F:19])[CH:16]=[C:15]([F:20])[CH:14]=3)[O:10][C:9]3[CH:29]=[CH:30][C:6]([C:4]([OH:5])=[O:3])=[CH:7][C:8]=3[O:12]2)[CH:26]=[C:25]([F:27])[CH:24]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 690590952,2-Bis-(3,5-difluoro-phenyl)-benzo[1,3]dioxole-5-carboxylic acid ethyl ester

Product 1

HCID 22475247HCID 22475247, compoundYield 81.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

267 mg 2,2-bis-(3,5-difluoro-phenyl)-benzo[1,3]dioxole-5-carboxylic acid ethyl ester, 3.8 mL ethyl alcohol and 0.96 mL 1N NaOH were stirred at room temperature for 6 h. The solvent was evaporated and the residue worked up with ethyl acetate, diluted hydrochloric acid and water. Purification on silica gel afforded 204 mg white crystals, m.p.: 96° C.; MS: 389 ([M−H]−).

Workup

  1. customThe solvent was evaporated
  2. customPurification on silica gel

Sources & evidence

ORD record
ord-e3eb8841dc264198a8eebcdbeb065f05
Source dataset
uspto-grants-2009_08
Patent number
US07576088B2

Reaction notes

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