HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 68913839, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1-Chloro-3-iodopropane | HCID 81363 | — |
| Reactant | HCID 10749523 | HCID 10749523 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | HCID 68913839 | HCID 68913839 | 48.1% |
Reaction Steps
5-Methyl-4H-benzo[1,4]oxazin-3-one (81MF941a) (1.514 g, 9.28 mmol), Cs2CO3 (4.53 g, 13.9 mmol) and 3-chloro-1-iodopropane (2.09 g, 10.21 mmol) were mixed according to GP6. CC (SiO2; Heptane/EtOAc 10:1-5) gave the title compound (81MF941b) (1.07 g, 48%). 1H NMR (CDCl3) δ 6.99-6.87 (m, 3H), 4.42 (s, 2H), 4.17 (t, J=7.2 Hz, 2H), 3.45 (t, J=6.4 Hz, 2H), 2.41 (s, 3H), 2.04-1.97 (m, 2H); 13C NMR (CDCl3) δ 168.3, 149.9, 129.1, 128.7, 126.9, 125.1, 115.0, 69.4, 42.2, 42.1, 30.6, 20.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576100B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-fe3dd48f493e4bddaf13ca02fe556bde |
| Source note | uspto-grants-2009_08 |