Sodium Hydroxide → HCID 24883358, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the product (143 mg, 0.4 mmol) from step 1 in 4:1 mixture of MeOH/water (2 mL) was added 2M solution of NaOH (241 uL, 0.48 mmol). Reaction mixture was heated at 50° C. for 16 h. Solvent was removed in vacuo, residue was washed with water, dissolved in MeOH and filtered. Filtrate was concentrated to give the product as white solid (155 mg, 100%): MS; m/z 342.5 (M+H); 1H NMR (400 MHz, DMSO-d6); δ 1.99 (br, 2H), 2.17-2.21 (m, 2H), 2.84-2.88 (m, 2H), 3.25-3.32 (m, 7H), 6.92-7.10 (m, 7H), 7.33-7.37 (m, 2H); HPLC (UV); 93%.

Provenance & Evidence