Hydrochloric Acid → 1-({[4-(Trifluoromethyl)pyridin-2-yl]methoxy}acetyl)pyrrolidin-3-amine

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	tert-butyl [(3S)-1-({[4-(trifluoromethyl)pyridin-2-yl]methoxy}acetyl)pyrrolidin-3-yl]carbamate	HCID 57803377	—
Solvent	Methanol	HCID 887	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	1-({[4-(Trifluoromethyl)pyridin-2-yl]methoxy}acetyl)pyrrolidin-3-amine	HCID 69005653	—

Reaction Steps

To a solution of tert-butyl [(3S)-1-({[4-(trifluoromethyl)pyridin-2-yl]methoxy}acetyl)pyrrolidin-3-yl]carbamate (300 mg, 0.74 mmol) in methanol (3 mL) was added a 4.0 M solution of HCl in 1,4-dioxane (6 mL). After being stirred for 0.5 h at room temperature, the solution was concentrated under vacuum to give the title compound. MS (M+H) 304.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07576089B2
Source dataset	uspto-grants-2009_08
ORD ID	ord-b5f6038a46de447590dcdaa858448693
Source note	uspto-grants-2009_08