Formaldehyde → HCID 86599993, compound

Participants

Reaction Steps

Potassium carbonate (6.6 g, 47.5 mmol) was added to a solution of 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)3-cyano-4-trifluoromethylthiopyrazole (5.0 g, 11.87 mmol) in iso-propanol, and stirred for five minutes before paraformaldehyde (0.75 g) was added. The resulting mixture was stirred at 20C for three days, then diluted with isopropanol (20 ml) and added to water and ethyl acetate. The organic layer was dried (sodium sulfate) and evaporated to give 1-(2,6-dichloro-4-trifluoromethylphenyl-3-cyano-5-1-propyloxymethylamino-4-trifluoromethylthiopyrazole (Compound number 14, 5.3 g).

Provenance & Evidence