1-Amino-2-propanol → HCID 86599994, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-bromo-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylsulfonylpyrazole (3.0 g, 5.8 mmol) in 1,4-dioxane was added 1-amino-2-propanol (0.52 g, 7.0 mmol) and triethylamine (0.76g, 7.5 mmol). The mixture was heated at 100° C. for 2 hours. After extractive workup and recrystallisation from heptane-ethyl acetate (1:1) there was obtained 1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-5-(2-hydroxypropylamino)-4-trifluoromethylsulfonylpyrazole (Compound number 1-5, 2.67 g), 19F: −64.2; −80.9.

Provenance & Evidence