HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → (E)-4-Cyclohexyl-2-(4-methanesulfonyl-phenyl)-but-2-en-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Diisobutylaluminum hydride | HCID 14487 | — |
| Reactant | (E)-4-Cyclohexyl-2-(4-methanesulfonyl-phenyl)-but-2-enoic acid ethyl ester | HCID 67084356 | — |
| Product | (E)-4-Cyclohexyl-2-(4-methanesulfonyl-phenyl)-but-2-en-1-ol | HCID 67084508 | 79.1% |
Reaction Steps
Following the method of example 54e, using (E)-4-cyclohexyl-2-(4-methanesulfonyl-phenyl)-but-2-enoic acid ethyl ester (956 mg, 2.73 mmol) and 3 h at ambient temperature after the addition of DIBAL in toluene (4.95 mL, 6.0 mmol) gives the title compound as an amorphous solid (666 mg). MS (m/e): 291 ([M−H2O]+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576108B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-6a03a8bf7da74ec4b257bcc0873a1da2 |
| Source note | uspto-grants-2009_08 |