反应详情

Add a suspension of oxone® (113 g, 183 mmol) in water (600 ml) to a solution of (E)-3-cyclopentyl-2-(4-methylsulfanyl-phenyl)-acrylic acid ethyl ester (24.2 g, 83 mmol) in acetone (600 ml). Stir overnight, and then add water (500 ml). Extract the resulting mixture with dichloromethane (2×500 ml). Combine the extracts, wash with brine (2×500 ml), dry over magnesium sulfate, and remove solvent under vacuum to afford the title compound as an off-white solid (25.8 g). MS (m/e): 323.4 (M+H).

1. additionAdd
2. extractionExtract the resulting mixture with dichloromethane (2×500 ml)
3. washCombine the extracts, wash with brine (2×500 ml)
4. dry with materialdry over magnesium sulfate
5. customremove solvent under vacuum