HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → (E)-3-Cyclopentyl-2-(4-(methylsulfonyl)phenyl)prop-2-EN-1-OL
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Diisobutylaluminum hydride | HCID 14487 | — |
| Reactant | (E)-3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-acrylic acid ethyl ester | HCID 67084405 | — |
| Product | (E)-3-Cyclopentyl-2-(4-(methylsulfonyl)phenyl)prop-2-EN-1-OL | HCID 53471256 | 100.3% |
Reaction Steps
Following the method of example 54e, reaction of DIBAL in toluene (268 ml, 1.5 M, 402 mmol) with (E)-3-cyclopentyl-2-(4-methanesulfonyl-phenyl)-acrylic acid ethyl ester (51.8 g, 160 mmol) affords the title compound as a solid (45 g). MS (m/e): 303.4 (M+Na).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576108B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-b6105a0cdad74e06bd0108c7437e0024 |
| Source note | uspto-grants-2009_08 |