HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium fluoride → (Z)-3-Cyclopentyl-2-(5-methanesulfonyl-thiophen-2-yl)-prop-2-en-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | 2-Bromo-5-methanesulfonylthiophene | HCID 17390281 | — |
| Reactant | 3-Cyclopentyl-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-prop-2-en-1-ol | HCID 67084717 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Product | (Z)-3-Cyclopentyl-2-(5-methanesulfonyl-thiophen-2-yl)-prop-2-en-1-ol | HCID 69055089 | 56.1% |
Reaction Steps
According to method 17a was used 2-bromo-5-methanesulfonyl-thiophene (593 mg, 2.46 mmol), caesium fluoride ( 747 mg, 4.92 mmol), tetrakis-(triphenylphosphin)-palladium(0) (142 mg, 0.123 mmol) and 3-cyclopentyl-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-prop-2-en-1-ol (620 g, 2.46 mmol) to give 395 mg of purified compound. MS (m/e): 309.0 (M+Na).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576108B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-1614bab49cd64e9aa521ac7e802bbdcd |
| Source note | uspto-grants-2009_08 |