HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium fluoride → (Z)-5-(2-Cyclopentyl-1-hydroxymethyl-vinyl)-thiophene-2-sulfonic acid dimethylaminomethyleneamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | N,N-Dimethyl-N'-(5-bromothiophene-2-sulfonyl)formamidine | HCID 54319951 | — |
| Reactant | (Z)-3-cyclopentyl-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-prop-2-en-1-ol | HCID 67487170 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Product | (Z)-5-(2-Cyclopentyl-1-hydroxymethyl-vinyl)-thiophene-2-sulfonic acid dimethylaminomethyleneamide | HCID 131727584 | — |
Reaction Steps
According to method 20b was used (Z)-3-cyclopentyl-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-prop-2-en-1-ol (678 mg, 2.69 mmol), 5-bromo-thiophene-2-sulfonic acid dimethylaminomethyleneamide (799 mg, 2.69 mmol), caesium fluoride ( 817 mg, 5.38 mmol) and tetrakis-(triphenylphosphin)-palladium(0) (155 mg, 0.135 mmol) to give 538 mg purified product. MS (m/e): 343.0 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576108B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-3f2468593725404da546ea12c1e04de0 |
| Source note | uspto-grants-2009_08 |