HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium fluoride → (E)-3-Cyclopentyl-2-(5-methanesulfonyl-thiophen-3-yl)-prop-2-en-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | 4-Bromo-2-methylsulfonyl-thiophene | HCID 20222293 | — |
| Reactant | (Z)-3-cyclopentyl-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-prop-2-en-1-ol | HCID 67487170 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Product | (E)-3-Cyclopentyl-2-(5-methanesulfonyl-thiophen-3-yl)-prop-2-en-1-ol | HCID 67484562 | — |
Reaction Steps
According to method 20b was used (Z)-3-cyclopentyl-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-prop-2-en-1-ol (252 mg, 1.0 mmol), 4-Bromo-2-methanesulfonyl-thiophene (241 mg, 1.0 mmol), caesium fluoride ( 304 mg, 2.0 mmol) and tetrakis-(triphenylphosphin)-palladium(0) (58 mg, 0.05 mmol) to give 100 mg purified product. MS (m/e): 309.0 (M+Na).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576108B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-c687ecaedd8540b6a5123b170f5261ce |
| Source note | uspto-grants-2009_08 |