2,5-Dibromopyridine → 5-Bromo-2-(methylthio)pyridine

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Reaction Steps

Add sodiumthiomethoxide (1.0 g, 14.4 mmol) to a suspension of 2,5-dibromo-pyridine (3.1 g, 13 mmol) in DMF (8 ml) at r.t. Stir for 2 h at r.t., dilute with water (20 ml) and extract 2 times with MTBE. Dry organic layers over sodium sulfate and remove solvents under vacuum to obtain 2.59 g of 5-bromo-2-methylsulfanyl-pyridine. MS (m/e): 205 (M+H).

Provenance & Evidence