HCID 178420200, compound → HCID 178419852, compound

Participants

Reaction Steps

The product of Example 51A (135.0 mg, 0.23 mmole) was dissolved in formic acid (88%, 2 ml) and stirred at room temperature for 2 hours. The reaction mixture concentrated was under reduced pressure. The solid residue was then treated with saturated aqueous sodium bicarbonate and extracted with dichloromethane (4×5 ml). The combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated to give the crude product which was purified by column chromatography (1% ammonium hydroxide and 10% methanol in dichloromethane) to give 71.2 mg (90.5%) of title compound. MS: (M+H)+=339.

Provenance & Evidence