Cyclohexanol, 1-(aminomethyl)-, hydrochloride (1:1) → 4-Chloro-7-{1-(tert-butoxycarbonyl)-5-[(1-hydroxycyclohexyl)methylaminomethyl]indol-2-yl}isoindolinone

Participants

Reaction Steps

In a similar manner to Step 1 of Example 56, 4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (20.0 mg, 0.0487 mmol) was dissolved in dichloromethane (0.5 mL). The solution was treated with 1-aminomethyl-1-cyclohexanol hydrochloride (13 mg, 0.10 mmol) and sodium triacetoxyborohydride (32 mg, 0.15 mmol) to obtain 4-chloro-7-{1-(tert-butoxycarbonyl)-5-[(1-hydroxycyclohexyl)methylaminomethyl]indol-2-yl}isoindolinone.

Provenance & Evidence