Potassium Hydroxide → HCID 69064141, compound

HRID 2103730Notes

Reaction equation

HRID 2103730 reaction equation
[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[CH2:7]1[CH:11]2[CH2:12][CH2:13][CH2:14][CH:10]2[CH2:9][N:8]1[CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]1[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][CH:21]=1.[OH-:28].[K+]>C(O)C.O>[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[CH2:9]1[CH:10]2[CH2:14][CH2:13][CH2:12][CH:11]2[CH2:7][N:8]1[CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]1[CH:27]=[CH:26][C:23]([C:24]([NH2:25])=[O:28])=[CH:22][CH:21]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 69063569HCID 69063569, compound

Product 1

HCID 69064141HCID 69064141, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

436 mg of the compound of Example 18 are dissolved in 4 ml of ethanol. 86 mg of potassium hydroxide (1 eq.) are dissolved in 1.5 ml of water before being added to the alcohol solution. The mixture is heated at reflux for 1.5 hours and then evaporated to dryness. The residue is taken up in dichloromethane. The resulting solution is washed with water, dried over magnesium sulphate and then concentrated in vacuo. The product is crystallised in oxalate form.

Workup

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 1.5 hours
  3. customevaporated to dryness
  4. washThe resulting solution is washed with water
  5. dry with materialdried over magnesium sulphate
  6. concentrationconcentrated in vacuo
  7. customThe product is crystallised in oxalate form

Sources & evidence

ORD record
ord-ae6d892506714d5b902fee1871b975a0
Source dataset
uspto-grants-2009_08
Patent number
US07576120B2

Reaction notes

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