Formaldehyde → HCID 9977025, compound

HRID 2103736Notes

Reaction equation

HRID 2103736 reaction equation
[CH2:1]([N:3]([CH2:26][CH3:27])[C:4](=[O:25])[C:5]1[CH:10]=[CH:9][C:8]([N:11]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[CH:7][CH:6]=1)[CH3:2].[CH2:28]=O.[BH4-].[Na+]>CO.O>[CH2:26]([N:3]([CH2:1][CH3:2])[C:4](=[O:25])[C:5]1[CH:6]=[CH:7][C:8]([N:11]([CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:12]2[CH2:17][CH2:16][N:15]([CH3:28])[CH2:14][CH2:13]2)=[CH:9][CH:10]=1)[CH3:27]

Participants

6

Reactant 3

HCID 712FormaldehydeHCID 4311764Sodium borohydrideHCID 10406550HCID 10406550, compound2×

Product 1

HCID 9977025HCID 9977025, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of N,N-diethyl-4-[benzyl(piperidin-4-yl)amino]benzamide (Compound 8) (0.67 g, 0.207 mmole) in 10 mL of methanol was added 37% formalin solution (1 mL), and the resulting mixture was cooled in an ice bath under Argon. To this mixture was added sodium borohydride (0.69 g, 18.2 mmol) in small portions. The reaction mixture was allowed to warm to ambient temperature and was stirred for three days. The reaction mixture was diluted with water (25 mL), and the resulting solution was extracted three times with chloroform (25 mL). The organic extracts were combined, dried (Na2SO4), and concentrated to provide a pale yellow oil. This material was purified on a flash silica gel column (10% methanol-chloroform to 15% methanol-chloroform) to provide 0.54 g of N,N-diethyl-4-[benzyl(1-methylpiperidin-4-yl)amino]benzamide as a pale yellow semisolid. This material was dissolved in acetonitrile, and oxalic acid (0.13 g) was added. Upon addition of diethyl ether, a cream-colored precipitate came out of solution. Recrystallization from acetonitrile and diethyl ether afforded 0.18 g (18% yield) of a cream-colored solid, mp 101-105° C. MS (ES), m/z 380 (MH+). 300 MHz 1H NMR (DMSO-d6) δ0.85-1.15 (br m, 6H), 1.75-2.02 (br m, 2H), 2.72 (s, 3H), 2.95-3.15 (br m, 2H), 3.16-3.45 (m, 6H), 4.12-4.30 (br m, 1H), 4.49 (br s, 2H), 6.63-6.82 (br m, 2H), 7.10-7.40 (m, 7H). Elemental analysis: Calculated for C24H33N3O.C2H2O4.0.6H2O: C, 65.01; H, 7.60; N, 8.75; H2O, 2.25. Found C, 64.77; H, 7.25; N, 8.59; Karl Fischer H2O, 1.55.

Workup

  1. temperaturethe resulting mixture was cooled in an ice bath under Argon
  2. extractionthe resulting solution was extracted three times with chloroform (25 mL)
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated
  5. customto provide a pale yellow oil
  6. customThis material was purified on a flash silica gel column (10% methanol-chloroform to 15% methanol-chloroform)

Sources & evidence

ORD record
ord-f834ed76f13041acaa35db7728f495ba
Source dataset
uspto-grants-2009_08
Patent number
US07576105B2

Reaction notes

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