7-Methylcoumarin → 7-(Bromomethyl)-2h-chromen-2-one

Participants

Reaction Conditions

Reaction Steps

To a solution of 7-methylcoumarin (50 g) in acetonitrile (1.2 L), N-bromosuccinimide (56 g) and α,α′-azobisisobutylonitrile (510 mg) were added, and the mixture was stirred for 30 minutes at 78° C. of inside temperature. The reaction mixture was concentrated, and water was added. The crystal was collected by filtration to give the title compound (76 g) having the following physical data.

Provenance & Evidence