Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisoamylamine | HCID 10988 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | [2-(2,2-Dimethylpropanoyl)-5-methoxy-1-benzofuran-3-yl]acetic acid | HCID 57804476 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 11396276 | HCID 11396276 | — |
Reaction Steps
Dissolve a mixture of 17 mg [2-(2,2-dimethylpropanoyl)-5-methoxy-1-benzofuran-3-yl]acetic acid from the Step B Example 1 and 18.5 mg HOBt in 1 mL dry DMF. Add 18.0 μL di-iso-amylamine followed by 23.0 mg EDC and 35 μL DIEA. This solution was heated at 40° C. for 2 hours. It was purified directly on RP-HPLC using 70-100% MeCN gradient. The fractions containing pure product were pooled and lyophilized to give the title compound. LC-MS: 4.67 min. (m/Z=430.4, 346.2, 452.2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07576122B2 |
|---|
| Source dataset | uspto-grants-2009_08 |
|---|
| ORD ID | ord-1c39843c05d045168f5c4f04592602c4 |
|---|
| Source note | uspto-grants-2009_08 |
|---|
