HCID 57804472, compound → HCID 11473469, compound

HRID 2103779Notes

Reaction equation

HRID 2103779 reaction equation
[OH:1][CH:2]([C:21]([CH3:24])([CH3:23])[CH3:22])[CH2:3][C:4]1[C:8]2[CH:9]=[C:10]([O:13][CH3:14])[CH:11]=[CH:12][C:7]=2[S:6][C:5]=1[C:15](=[O:20])[C:16]([CH3:19])([CH3:18])[CH3:17]>CC#N>[CH3:17][C:16]([CH3:19])([CH3:18])[C:15]([C:5]1[S:6][C:7]2[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:8]=2[C:4]=1[CH2:3][C:2](=[O:1])[C:21]([CH3:22])([CH3:23])[CH3:24])=[O:20]

Participants

3

Reactant 1

HCID 57804472HCID 57804472, compound

Product 1

HCID 11473469HCID 11473469, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound was prepared from 1-[3-(2-hydroxy-3,3-dimethylbutyl)-5-methoxy-1-benzothien-2-yl]-2,2-dimethylpropan-1-one from the Step A above using the procedure in Step B, Example 18. It was isolated as a white solid following RP-HPLC purification (70˜100% MeCN) and lyophilization. 1H NMR (CDCl3, 500 MHz) 7.72 (d, 8.9 Hz, 1H), 7.13 (dd, 2.4 & 8.8 Hz, 1H), 7.03 (d, 2.6 Hz, 1H), 4.40 (s, 2H), 3.88 (s, 3H), 1.41 (s, 9H), 1.35 (s, 9H). LC-MS: 4.27 min. (m/Z=369.2, 263.2, 347.3).

Workup

  1. custom4.27 min. (m/Z=369.2, 263.2, 347.3)

Sources & evidence

ORD record
ord-1161a717d3b84ad1bdf274ea637a5361
Source dataset
uspto-grants-2009_08
Patent number
US07576122B2

Reaction notes

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