反应详情

Acetic anhydride (1.89 mL, 20 mmol) was added to a suspension of 3-amino-4-methoxycarbonylbenzoic acid (1.95 g, 10 mmol) in acetic acid (10 mL), and the mixture was heated with reflux for 6 hours. After cooling, the precipitated solid was filtered to obtain 2.12 g of the desired product as a colorless solid (yield 89%).

1. temperaturethe mixture was heated
2. temperaturewith reflux for 6 hours
3. temperatureAfter cooling
4. filtrationthe precipitated solid was filtered