反应详情

温度

100 °C

2-Oxopropanal methylhydrazone (46.375 mmol, 4.64 g) synthesized in Reference Synthetic Example 1 and (4-tert-butylphenyl)(oxo)acetaldehyde synthesized in Reference Synthetic Example 4 (46.375 mmol, 8.82 g) were dissolved is in acetic acid (140 mL) and stirred at 100° C. for 2 hours. The reactor was cooled to room temperature, and after addition of water (100 mL) and saturated aqueous sodium chloride (50 mL), it was extracted with chloroform three times. The resulting organic layer was dried and filtered, and the solvent was evaporated. The residue was purified by silica gel column chromatography (n-hexane/ethyl acetate=4/1) to give the desired product as a yellow solid (5.79 g, yield 46%).

1. dissolutionwere dissolved
2. temperatureThe reactor was cooled to room temperature
3. extractionwas extracted with chloroform three times
4. customThe resulting organic layer was dried
5. filtrationfiltered
6. customthe solvent was evaporated
7. customThe residue was purified by silica gel column chromatography (n-hexane/ethyl acetate=4/1)