反应详情

温度

100 °C

2-Oxopropanal ethylhydrazone (4.736 mmol, 540.6 mg) synthesized in Reference Synthetic Example 2 and (4-tert-butylphenyl)(oxo)acetaldehyde (4.736 mmol, 901.0 mg) synthesized in Reference Synthetic Example 4 were dissolved in acetic acid (20 mL) and stirred at 100° C. for about 3.5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel thin layer chromatography (n-hexane/AcOEt=1/2, 3/1 and 4/1) to give the desired product as an orange liquid (212 mg, yield 16%).

1. customsynthesized in Reference Synthetic Example 4
2. customThen, the solvent was evaporated
3. customthe residue was dried by means of a vacuum pump
4. custompurified by silica gel thin layer chromatography (n-hexane/AcOEt=1/2, 3/1 and 4/1)