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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2103894Generated: November 1, 2026

2-(4-t-Butylphenyl)-3-hydroxy-4-methylcarbonylthiophene → Methyl 2-chloro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate

https://huagongshe.com/reaction/2103894

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(4-t-Butylphenyl)-3-hydroxy-4-methylcarbonylthiopheneHCID 44207289—
ReactantMethyl 2-chloro-4-hydrazinocarbonylbenzoateHCID 67050317—
ProductMethyl 2-chloro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoateHCID 72360019—

Reaction Steps

Using 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (55 mg, 0.20 mmol) and methyl 2-chloro-4-hydrazinocarbonylbenzoate (50 mg, 0.22 mmol) as the starting materials, the desired product was obtained in the same manner as in Synthetic Example 65 as a pale yellow solid (86 mg, yield 89%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07576115B2
Source datasetuspto-grants-2009_08
ORD IDord-ef5e8866433541c29eaba06ac343f925
Source noteuspto-grants-2009_08