1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone → 5-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylic acid

HRID 2103915Notes

Reaction equation

HRID 2103915 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH3:13])[N:11]=[C:10]([C:14](=O)[CH3:15])[C:9]=2[OH:17])=[CH:4][CH:3]=1.[NH:18]([C:20]([NH:22][C:23]1[S:27][C:26]([C:28]([OH:30])=[O:29])=[CH:25][CH:24]=1)=[S:21])[NH2:19]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH3:13])[N:11]=[C:10]([C:14](=[N:19][NH:18][C:20]([NH:22][C:23]3[S:27][C:26]([C:28]([OH:30])=[O:29])=[CH:25][CH:24]=3)=[S:21])[CH3:15])[C:9]=2[OH:17])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 670501011-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanoneHCID 860144975-Hydrazinocabonothioylamino-2-thiophenecarboxylic acid

Product 1

HCID 723600695-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylic acid

Procedure

From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (37.5 mg, 0.15 mmol) and 5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (33 mg, 0.14 mmol), the desired product was obtained in the same manner as in Synthetic Example 114 as a pale yellow solid (62.0 mg, yield 83%).

Sources & evidence

ORD record
ord-9944fde1379746ecb159f540dcf1e4f0
Source dataset
uspto-grants-2009_08
Patent number
US07576115B2

Reaction notes

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