Acetic acid 4-acetyl-2-(3,4-dichlorophenyl)thiophen-3-yl ester → 4-{1-[4-Acetoxy-5-(3,4-dichlorophenyl)thiphen-3-yl]ethylidenehydrazinocarbonyl}-2-nitrobenzoic acid

HRID 2103923Notes

Reaction equation

HRID 2103923 reaction equation
[C:1]([C:4]1[C:5]([O:17][C:18](=[O:20])[CH3:19])=[C:6]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=2)[S:7][CH:8]=1)(=O)[CH3:2].[NH:21]([C:23]([C:25]1[CH:33]=[CH:32][C:28]([C:29]([OH:31])=[O:30])=[C:27]([N+:34]([O-:36])=[O:35])[CH:26]=1)=[O:24])[NH2:22]>>[C:18]([O:17][C:5]1[C:4]([C:1](=[N:22][NH:21][C:23]([C:25]2[CH:33]=[CH:32][C:28]([C:29]([OH:31])=[O:30])=[C:27]([N+:34]([O-:36])=[O:35])[CH:26]=2)=[O:24])[CH3:2])=[CH:8][S:7][C:6]=1[C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=1)(=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 67050150Acetic acid 4-acetyl-2-(3,4-dichlorophenyl)thiophen-3-yl esterHCID 670502974-Hydrazinocarbonyl-2-nitrobenzoic acid

Product 1

HCID 723599604-{1-[4-Acetoxy-5-(3,4-dichlorophenyl)thiphen-3-yl]ethylidenehydrazinocarbonyl}-2-nitrobenzoic acid

Procedure

The title compound was prepared from acetic acid 4-acetyl-2-(3,4-dichlorophenyl)thiophen-3-yl ester (39.5 mg, 0.12 mmol) and 4-hydrazinocarbonyl-2-nitrobenzoic acid (40.5 mg, 0.18 mmol) following the procedure described in the synthetic example 185.

Sources & evidence

ORD record
ord-a62af9343996489a8873053be9796dd6
Source dataset
uspto-grants-2009_08
Patent number
US07576115B2

Reaction notes

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