Acetic acid 4-acetyl-2-(3,4-dichlorophenyl)thiophen-3-yl ester → 4-(2-{1-[4-Acetoxy-5-(3,4-dichlorophenyl)thiphen-3-yl]ethylidene}hydrazinecarbothioamido)-2-chlorobenzoic acid

HRID 2103924Notes

Reaction equation

HRID 2103924 reaction equation
[C:1]([C:4]1[C:5]([O:17][C:18](=[O:20])[CH3:19])=[C:6]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=2)[S:7][CH:8]=1)(=O)[CH3:2].[Cl:21][C:22]1[CH:30]=[C:29]([NH:31][C:32]([NH:34][NH2:35])=[S:33])[CH:28]=[CH:27][C:23]=1[C:24]([OH:26])=[O:25]>>[C:18]([O:17][C:5]1[C:4]([C:1](=[N:35][NH:34][C:32](=[S:33])[NH:31][C:29]2[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[C:22]([Cl:21])[CH:30]=2)[CH3:2])=[CH:8][S:7][C:6]=1[C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=1)(=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 67050150Acetic acid 4-acetyl-2-(3,4-dichlorophenyl)thiophen-3-yl esterHCID 860144984-Hydrazinocabonothioylamino-2-chlorobenzoic acid

Product 1

HCID 723599514-(2-{1-[4-Acetoxy-5-(3,4-dichlorophenyl)thiphen-3-yl]ethylidene}hydrazinecarbothioamido)-2-chlorobenzoic acid

Procedure

The title compound was prepared from acetic acid 4-acetyl-2-(3,4-dichlorophenyl)thiophen-3-yl ester (39.5 mg, 0.12 mmol) and 2-chloro-4-(hydrazinecarbothioamido)benzoic acid (40.5 mg, 0.132 mmol) following the procedure described in the synthetic example 185.

Sources & evidence

ORD record
ord-cf162d99ada047c7a1a50250d3781c38
Source dataset
uspto-grants-2009_08
Patent number
US07576115B2

Reaction notes

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