Sodium Hydroxide → 3-[[4-(5-oxo-2H-1,2,4-oxadiazol-3-yl)benzoyl]amino]propanoic acid

HRID 2103934Notes

Reaction equation

HRID 2103934 reaction equation
C([O:3][C:4](=[O:22])[CH2:5][CH2:6][NH:7][C:8](=[O:21])[C:9]1[CH:14]=[CH:13][C:12]([C:15]2[NH:16][O:17][C:18](=[O:20])[N:19]=2)=[CH:11][CH:10]=1)C.[OH-].[Na+]>O1CCOCC1.O>[O:17]1[C:18](=[O:20])[N:19]=[C:15]([C:12]2[CH:13]=[CH:14][C:9]([C:8]([NH:7][CH2:6][CH2:5][C:4]([OH:22])=[O:3])=[O:21])=[CH:10][CH:11]=2)[NH:16]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178472065HCID 178472065, compound

Product 1

HCID 1785255983-[[4-(5-oxo-2H-1,2,4-oxadiazol-3-yl)benzoyl]amino]propanoic acid

Reagents, catalysts & solvents 1

HCID 218864351,4-Dioxane--water (1/1)Solvent

Procedure

Compound 3 (0.60 g, 2.0 mmol) was dissolved in a mixture of 1,4-dioxane/H2O (10 mL, 1/1, v/v). Aq. NaOH (2.0 mL, 2N) was added and the mixture was stirred for 3 h at RT. The reaction mixture was neutralized with Dowex H+ and filtered. The filtrate was concentrated under reduced pressure and the resulting white solid was dried under vacuum. Yield 0.51 g (93%).

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. customthe resulting white solid was dried under vacuum

Sources & evidence

ORD record
ord-564e01b277b74215a950dae5fe98314a
Source dataset
uspto-grants-2009_08
Patent number
US07576071B2

Reaction notes

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