反应详情

10 mmole of 1H-1,2,4-triazole-3-thiol was dissolved in 20 ml of ethanol in stirring. 10 mole of EtOK was added to the solution, stirred for 5 minutes. Then, 10 mmole of 4-vinylbenzene chloride was added, and stirred overnight. The white precipitate was removed by filtration, the solvent in the filtrate was removed in vacuum. The filtrate was separated with a Si gel column (solvents: 4 ethylacetate/hexane). 1.79 g product as white solid was obtained. Yield: 83%. 1H NMR (CD3Cl): 8.73 (1H, s), 7.36 (4H, m), 6.75 (1H, m), 5.85 (1H, d, JH-H=17.66), 3.25 (1H, d, JH-H=10.93), 4.31 (2H, S).

1. stirringstirred for 5 minutes
2. stirringstirred overnight
3. customThe white precipitate was removed by filtration
4. customthe solvent in the filtrate was removed in vacuum
5. customThe filtrate was separated with a Si gel column (solvents: 4 ethylacetate/hexane)