Sodium Iodide → HCID 178447698, compound

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Reaction Steps

5-bromopent-1-ene (10 mmol) and NaI were dissolved in 30 ml MeOH and stirred at room temperature for 12 h. 10 mmol 3-mercapto-1H-1,2,4-triazole (potassium salt) in 10 ml MeOH was added to above solution and further stirred for 24 hours. After the solvent MeOH was evaporated in vacuum, a mixture of hexane and ethyl acetate (1/1 in volume) 100 ml was added and stirred for 5 minutes. The precipitate was removed by filtration. The solvent in the filtrate was removed in vacuum. The residual was separated with a Si gel column (solvents: 1 ethyl acetate/1 hexane in volume). 1.2 g product was obtained as colorless oil. Yield: 71%. 1H NMR (CDCl3): 10.83 (1H, brs.), 8.17 (1H, s), 5.75 (1H, m), 4.99 (2H, m), 3.16 (2H, t), 2.19 (2H, m), 1.82 (2H, m).

Provenance & Evidence