Benzyl Alcohol → HCID 17830651, compound

Participants

Reaction Steps

To a solution of sodium hydride (3.2 g, 80 mmol) in DMF (20 ml) was added under ice-cooling benzylalcohol (8.6 g, 80 mmol). To the solution was added 2,4-dichloro-6-methylpyrimidine (3.2 g, 20 mmol). The mixture was stirred at room temperature for 1 hour. To the reaction mixture was added an aqueous solution of ammonium chloride. The mixture was extracted with diethyl ether, washed with water, dried and concentrated. The obtained residue was chromatographed on silica gel (n-hexane-ethyl acetate). The obtained fraction was concentrated under reduced pressure to give 2,4-bisbenzyloxy-6-methylpyrimidine (3.5 g).

Provenance & Evidence