HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-Trityl-1,2,4-triazole-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 9-Borabicyclo(3.3.1)nonane | HCID 78966 | — |
| Reactant | 2'-Iodoacetophenone | HCID 240431 | — |
| Reactant | 2-Trityl-2H-tetrazol-5-carboxylic Acid Ethyl Ester | HCID 67077033 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Trityl-1,2,4-triazole-3-carboxylic acid ethyl ester | HCID 57424168 | — |
Reaction Steps
To Resin A (30 mg) was added THF (0.4 ml). To the mixture was added 9-BBN (0.5M in THF, 0.4 ml). The mixture was stirred at room temperature for 4 hours. To the mixture was added an aqueous solution of potassium carbonate (2M, 0.1 ml), 2-acetyliodobenzene (41 mg, 0.2 mmol) and PdCl2(dppf) (3 mg). The mixture was stirred at 50° C. for 20 hours. The obtained resin was washed with DMF, water, methanol and methylene chloride to give Resin B.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576198B1 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-66b51324ab55474fb2a133c5c1f532f7 |
| Source note | uspto-grants-2009_08 |