1-Methanesulfonyl-piperidine-4-carboxylic acid benzyl ester → 1-Methanesulfonylpiperidine-4-carboxylic acid

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Reaction Steps

1-Methanesulfonyl-piperidine-4-carboxylic acid benzyl ester (0.8 g, 26.7 mmol) from step 4, was dissolved in ethyl acetate (100 ml) and methanol (10 ml), Pd/C 10% (80 mg) was added and the resulting mixture was hydrogenated at 1 bar. The catalyst was filtered over celite, the solvent was removed under reduced pressure to give a white solid. Yield 73%, 0.4 g.

Provenance & Evidence