HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → 1-benzylazetidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-benzylazetidin-3-ol | HCID 3801345 | — |
Reaction Steps
reacting (±)-2-(chloromethyl)oxirane, sodium bicarbonate and benzylamine in acetonitrile and water to provide 1-benzyl-3-azetidinol, reacting the 1-benzyl-3-azetidinol and (2E/Z)-2-butenedioic acid at about 35° C. to about 45° C., and isolating 1-benzyl-3-azetidinol (2E/Z)-2-butenedioate;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576216B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-8f108ea799514a1f8d4c48f21b31c22b |
| Source note | uspto-grants-2009_08 |