3,5-Heptanedione → HCID 11523520, compound

Participants

Reaction Steps

The title compound was prepared according to the general procedure of method A. The (2-Amino-5-bromo-phenyl)-phenyl-methanone [example A16] (on 0.1-1 g scale) and 3,5-heptanedione (1.5 equiv) and sodium tetrachloroaureate(III) dihydrate (0.025 equiv) were heated in parallel in a Radley carousel under nitrogen in ethanol (10% w/w-solution of (2-Amino-5-bromo-phenyl)-phenyl-methanone) and reacted for 24 h. The reaction mixture was evaporated to dryness and the residue purified by chromatography on silica gel in heptane/ethyl acetate (20:1). Yield: 37%. MS: m/z=368 (M).

Provenance & Evidence