HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-bromobenzophenone → 1-(6-Bromo-2-methyl-4-phenyl-quinolin-3-yl)-2,2-difluoro-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-bromobenzophenone | HCID 99677 | — |
| Reactant | 1,1-Difluoropentane-2,4-dione | HCID 2778488 | — |
| Product | 1-(6-Bromo-2-methyl-4-phenyl-quinolin-3-yl)-2,2-difluoro-ethanone | HCID 11717755 | 36% |
Reaction Steps
The title compound was prepared from (2-Amino-5-bromo-phenyl)-phenyl-methanone [example A16] and 1,1-difluoroacetylacetone according to the procedure of example 1, except that the residue was purified by chromatography on aminated silica gel with heptane/ethyl acetate (5:1). Yield: 36%. MS: m/z=377 (M).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576217B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-3f18507b52cb44dbbff672f1d2ff8395 |
| Source note | uspto-grants-2009_08 |