Pyrrolidine → 2,2,2-Trifluoro-1-[4-(4-methanesulfonyl-phenyl)-2-methyl-6-pyrrolidin-1-yl-quinolin-3-yl]-ethanone

Participants

Role	Name	HCID	Charge
Reactant	Pyrrolidine	HCID 31268	—
Reactant	1-[6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone	HCID 11540085	—
Product	2,2,2-Trifluoro-1-[4-(4-methanesulfonyl-phenyl)-2-methyl-6-pyrrolidin-1-yl-quinolin-3-yl]-ethanone	HCID 11583485	51%

Reaction Steps

The title compound was prepared from 1-[6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone [example 23] and pyrrolidine according to the procedure of example 25, except that the reaction time was of 16 h. Yield: 51%; MS: m/z=463 (M+H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07576217B2
Source dataset	uspto-grants-2009_08
ORD ID	ord-1b87e3afa5844458b688df3256c4484f
Source note	uspto-grants-2009_08