4-Phenylpiperidin-4-ol → HCID 67548444, compound

HRID 2104176Notes

Reaction equation

HRID 2104176 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[C:6]([C:13](=[O:18])[C:14]([F:17])([F:16])[F:15])=[C:5]2[C:19]1[CH:24]=[CH:23][C:22](F)=[CH:21][CH:20]=1.[OH:26][C:27]1([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[F:15][C:14]([F:17])([F:16])[C:13]([C:6]1[C:7]([CH3:12])=[N:8][C:9]2[C:4]([C:5]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[CH:3][C:2]([N:30]1[CH2:31][CH2:32][C:27]([OH:26])([C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)[CH2:28][CH2:29]1)=[CH:11][CH:10]=2)=[O:18]

Participants

3

Reactant 2

HCID 963874-Phenylpiperidin-4-olHCID 11567771HCID 11567771, compound

Product 1

HCID 67548444HCID 67548444, compoundYield 29%

Procedure

The title compound was prepared from 1-[6-Bromo-4-(4-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone [example 24] and 4-hydroxy-4-phenylpiperidine according to the procedure of example 25, except that the reaction time was of 16 h. Yield: 29%; MS: m/z=491 (M+H).

Sources & evidence

ORD record
ord-a8beca63263449519f438e2061588522
Source dataset
uspto-grants-2009_08
Patent number
US07576217B2

Reaction notes

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