4-Phenylpiperidin-4-ol → 2,2,2-Trifluoro-1-[6-(4-hydroxy-4-phenyl-piperidin-1-yl)-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-ethanone

Participants

Role	Name	HCID	Charge
Reactant	4-Phenylpiperidin-4-ol	HCID 96387	—
Reactant	1-[6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone	HCID 11540085	—
Product	2,2,2-Trifluoro-1-[6-(4-hydroxy-4-phenyl-piperidin-1-yl)-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-ethanone	HCID 67549852	17%

Reaction Steps

The title compound was prepared from 1-[6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone [example 24] and 4-hydroxy-4-phenylpiperidine according to the procedure of example 25, except that the reaction time was of 16 h. Yield: 17%; MS: m/z=569 (M+H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07576217B2
Source dataset	uspto-grants-2009_08
ORD ID	ord-d9e175e111164f65bed5df38cd41f625
Source note	uspto-grants-2009_08