HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxypiperidine → 2,2,2-Trifluoro-1-[4-(4-methanesulfonyl-phenyl)-6-(4-methoxy-piperidin-1-yl)-2-methyl-quinolin-3-yl]-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxypiperidine | HCID 77666 | — |
| Reactant | 1-[6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone | HCID 11540085 | — |
| Product | 2,2,2-Trifluoro-1-[4-(4-methanesulfonyl-phenyl)-6-(4-methoxy-piperidin-1-yl)-2-methyl-quinolin-3-yl]-ethanone | HCID 11677813 | 14% |
Reaction Steps
The title compound was prepared from 1-[6-bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone [example 23] and 4-methoxy-piperidine according to the procedure of example 25. Yield: 14%; MS: m/z=507 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576217B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-5ce362a5c9db4f10ba803035b930a2cd |
| Source note | uspto-grants-2009_08 |