HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone → 2,2,2-Trifluoro-1-[4-(4-methanesulfonyl-phenyl)-2-methyl-6-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-quinolin-3-yl]-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone | HCID 11540085 | — |
| Reactant | 8-Oxa-3-azabicyclo[3.2.1]octane | HCID 12069231 | — |
| Product | 2,2,2-Trifluoro-1-[4-(4-methanesulfonyl-phenyl)-2-methyl-6-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-quinolin-3-yl]-ethanone | HCID 11620362 | 61% |
Reaction Steps
The title compound was prepared from 1-[6-bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone [example 23] and 8-oxa-3-aza-bicyclo[3.2.1]octane according to the procedure of example 51. Yield: 61%; MS: m/z=505 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576217B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-6c83c255309745b992707045cb2882a8 |
| Source note | uspto-grants-2009_08 |