反应详情

PCC (30 g, 0.139 mmol) and well-dried 4 Å molecular shives (25 g) are added into a flask under N2 current. Dry CH2Cl2 (250 ml) is added to the flask and the flask is stirred for 1 hour at a room temperature and cooled to 0° C. The compound (VI) (16 g, 33.6 mmol) dissolved in dry CH2Cl2 (250 ml) is added to and stirred 4 hours at a room temperature. The reaction is finished with adding cool Et2O (200 ml) and filtered by silica gel. The solvent is vacuum concentrated, and then the compound (VII) (13.54 g, 85%) is isolated using flash column chromatography (toluene/EtOAc, 10:1, v/v).

1. additionare added into a flask under N2 current
2. temperaturecooled to 0° C
3. additionis added to and
4. stirringstirred 4 hours at a room temperature
5. additionwith adding
6. filtrationfiltered by silica gel
7. concentrationconcentrated