HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfate → 1-Chloro-2-methoxy-4-methylbenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfate | HCID 6497 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-5-methylphenol | HCID 12008 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Chloro-2-methoxy-4-methylbenzene | HCID 99352 | — |
Reaction Steps
A mixture of 2-chloro-5-methylphenol (14.2 g, 1 equiv), Me2SO4 (10.5 mL, 1.1 equiv) and K2CO3 (27.6 g, 2 equiv) in 150 mL of THF was stirred at rt overnight. Ethyl acetate and water were added and the organic layer was dried over sodium sulfate, filtered and evaporated to give 2-chloro-5-methylanisole as a crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576218B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-f7ccf0fff05945de8c1d9fa1459c3b0b |
| Source note | uspto-grants-2009_08 |