HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Chloro-3-methoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Chloro-2-methoxy-4-methylbenzene | HCID 99352 | — |
| Reactant | Potassium Permanganate | HCID 516875 | — |
| Catalyst | Tetrabutylammonium Chloride | HCID 70681 | — |
| Product | 4-Chloro-3-methoxybenzoic acid | HCID 2063378 | — |
Reaction Steps
2-chloro-5-methylanisole (31.2 g, 1 equiv) and Bu4NCl (2 g, cat.) in 500 mL of water was treated with 95 g of KMnO4 at reflux for 3 hours. The mixture was then filtered through celite, acidified with conc. HCl and the white solid was collected after filtration and air dry to give 4-chloro-3-methoxybenzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576218B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-bc674fae0739438cb2525a65f17f9ca5 |
| Source note | uspto-grants-2009_08 |