HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → Methyl 4-chloro-3-methoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 4-Chloro-3-methoxybenzoic acid | HCID 2063378 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 4-chloro-3-methoxybenzoate | HCID 44886974 | — |
Reaction Steps
4-chloro-3-methoxybenzoic acid (4.5 g) and 0.5 g of PTSA in 100 mL of dry methanol was refluxed for 3 hours. Evaporation and redissoving in ethyl acetate followed by washing with sodium bicarbonate, and concentration, gave methyl 4-chloro-3-methoxybenzoate without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576218B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-fe794d54465e4a47b94bf40d659d8975 |
| Source note | uspto-grants-2009_08 |