Formic Acid → HCID 57481674, compound

Participants

Reaction Steps

To the thus-obtained 4-methoxy-1-cyclopentene were added 88% formic acid (90 mL) and 30% hydrogen peroxide (3.17 mL) at room temperature, and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and 35% aqueous sodium hydroxide was added to the residue, to thereby make the reaction mixture basic, followed by stirring at 50° C. for 10 minutes. The resultant mixture was cooled to room temperature, and was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled away. The residue was purified by silica gel column chromatography (methanol:methylene chloride=1:19), to thereby give the title compound (1.21 g).

Provenance & Evidence